产品货号：
Z14577
中文名称：
FLI1抗体
英文名称：
Anti-FLI1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-FLI1 Antibody |
| 指标别名 | EWSR2;FLI1;Proto oncogene Fli 1;SIC 1;Transcription factor ERGB |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | IHC,WB |
| 基因名称 | FLI1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human FLI1(54-73aa QQEWINQPVRVNVKREYDHM),identical to the related rat and mouse sequences. |
| 实际分子量 | 51KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Friend leukemia integration 1 transcription factor,also known as Transcription factor ERGB or Proto-oncogene Fli-1 is a protein that in humans is encoded by the human FLI1 gene.The fli1 protooncogene encodes a member of the ETS family of winged helix-turn-helix transcription factors.This gene is mapped to 11q24.3.Fli-1 is activated through retroviral insertional mutagenesis in 90% of F-MuLV-induced erythroleukemias.The constitutive activation of fli-1 in erythroblasts leads to a dramatic shift in the Epo/Epo-R signal transduction pathway,blocking erythroid differentiation,activating the Ras pathway,and resulting in massive Epo-independent proliferation of erythroblasts.These results suggest that Fli-1 overexpression in erythroblasts alters their responsiveness to Epo and triggers abnormal proliferation by switching the signaling event(s) associated with terminal differentiation to proliferation. |
| Uniprot ID | Q01543 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | Friend leukemia virus integration 1 |
| 蛋白名全称 | Friend leukemia integration 1 transcription factor |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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